New drugs to prevent organ inflammation injury and acute kidney injury
About the Company
Arch is the leader in making peptides, antibodies and small molecules that target organ inflammation injury caused by the enzyme Dipeptidase-1 (DPEP1).
Arch is developing a drug platform to inhibit inflammation injury in the kidneys, lungs and liver. The company holds a suite of patented Dipeptidase-1 (DPEP1) inhibiting drug candidates designed to prevent organ injury caused by the DPEP1 inflammatory pathway.
- There are no effective drug treatments for acute organ inflammation on the market.
- The global anti-inflammatory therapeutics market size was approximately $102.37 billion (USD) in 2022, it’s expected to reach USD $127.5 billion by 2030.
Our platform
In August 2019, a scientific team led by Arch scientists Dr. Donna Senger and Dr. Stephen Robbins published a paper in the journal Cell (2019). The team identified DPEP1 for the first time as a major leukocyte (white blood cell) adhesion receptor on the lung, liver and kidney endothelium.
In the publication, DPEP1 was also identified as the target of LSALT peptide (the company’s lead drug candidate), differing from typical anti-inflammatory drugs by targeting this novel adhesion receptor rather than targeting individual cytokines.
- The company holds a strong patent position for its two lead drug candidates LSALT peptide and Cilastatin, two DPEP1 inhibitors with the potential to play a major role preventing acute kidney injury (AKI).
- Six million people are affected annually by AKI in the U.S. There is no treatment for kidney failure – patients require dialysis or a kidney transplant to survive.
- Approval of LSALT peptide to treat cardiac surgery-associated acute kidney injury (CS-AKI) will enable off-label use for other indications such as lung or liver inflammation injury, other AKI indications and septic shock.
- Cilastatin was originally developed by Merck to protect one of their antibiotics from being degraded by DPEP1. The drug has been shown to play a major role in toxin related kidney injury.
Arch Biopartners approach
Arch has a long history of working closely with the scientific community, universities and research institutions. The company’s mission is to advance and build the value of select medical innovations, develop the most promising intellectual property, and create value for its investors.
An experienced group of scientists with an executive, board and advisors bringing deep scientific, pharmaceutical, biotechnology and corporate financial experience.
Science and Research
- Current work on LSALT Peptide (Metablok) is directed by Arch’s larger Treatments for Inflammation Team, led by Dr. Daniel Muruve (Arch Biopartners CSO), Dr. Justin Macdonald Ph. D. and Dr. Arthur Lau Ph. D (Arch Biopartners Project Director) who are primarily based at the University of Calgary. Dr. David Luke, BScPhm, PharmD, is a Strategic Advisor and Senior Clinical Lead working to support the Board of Directors and the company’s ongoing clinical trials with LSALT peptide
- The DPEP1 Inflammation Pathway and LSALT Peptide were discovered by the Metablok team – Dr. Stephen Robbins Ph. D., Dr. Donna Senger Ph. D. and Jennifer Rahn B Sc., M Sc. at the University of Calgary.
The Arch science team also includes:
- Dr. Randall Irvin Ph. D., Professor Emeritus at the University of Alberta, whose work on the BORG Peptide is not currently under commercial development.
Executive, Board of Directors and Advisors
- Executives and Founders, CEO Richard Muruve, CSO Dr. Daniel Muruve and CFO Andrew Bishop form the management team
- Board of Directors, includes a group of key directors and strategic advisors
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