Authors

Saurav Roy Choudhury, Liane Babes, Jennifer J. Rahn, Bo-Young Ahn, Kimberly-Ann R. Goring, Jennifer C. King, Arthur Lau, Björn Petri, Xiaoguang Hao, Andrew K. Chojnacki, Ajitha Thanabalasuriar, Erin F. McAvoy, Sébastien Tabariès, Christoph Schraeder, Kamala D. Patel, Peter M. Siegel, Karen A. Kopciuk, David C. Schriemer, Daniel A. Muruve, Margaret M. Kelly, Bryan G. Yipp, Paul Kubes, Stephen M. Robbins, Donna L. Senger

Details

Published in the journal Cell, Volume 178, Issue 5, Pg1205-1221.E17, August 22, 2019
DOI: https://doi.org/10.1016/j.cell.2019.07.017
Read the full publication online at Cell or view the PDF version

Highlights

• Dipeptidase 1 (DPEP1) serves as a vascular adhesion molecule in lungs and liver
• DPEP1 acts as a physical adhesion receptor independent of its dipeptidase activity
• Targeting DPEP1 reduces mortality in murine models of sepsis

Abstract

A hallmark feature of inflammation is the orchestrated recruitment ...

Authors

Arthur Lau, Hyunjae Chung, Takanori Komada, Jaye M. Platnich, Christina F. Sandall, Saurav Roy Choudhury, Justin Chun, Victor Naumenko, Bas G.J. Surewaard, Michelle C. Nelson, Annegret Ulke-Lemée, Paul L. Beck, Hallgrimur Benediktsson, Anthony M. Jevnikar, Sarah L. Snelgrove, Michael J. Hickey, Donna L. Senger, Matthew T. James, Justin A. Macdonald, Paul Kubes, Craig N. Jenne, Daniel A. Muruve

Details

Published in JCI, The Journal of Clinical Investigation, June 4, 2018
J Clin Invest. 2018 Jul 2;128(7):2894-2913. doi: 10.1172/JCI96640. Epub 2018 Jun 4.
Read the article online at JCI read the PDF version (JCI) – also available from the NIH PMC

Abstract

Radiographic contrast agents cause acute kidney injury (AKI), yet the underlying pathogenesis is poorly understood. Nod-like receptor pyrin containing 3–deficient (Nlrp3-deficient) mice displayed reduced epithelial cell injury and inflammation in the kidney in a model of contrast-induced AKI ...

Authors

Simon A. Hirota, PhD, Jeffrey Ng, MSc, Alan Lueng, Maitham Khajah, PhD, Ken Parhar, MD, Yan Li, MSc, Victor Lam, BSc, Mireille S. Potentier, Kelvin Ng, Misha Bawa, BSc, Donna-Marie McCafferty, PhD, Kevin P. Rioux, MD, PhD, Subrata Ghosh, MD, Ramnik J. Xavier, MD, Sean P. Colgan, PhD, Jurg Tschopp, PhD, Daniel Muruve, MD, Justin A. MacDonald, PhD, Paul L. Beck, MD, PhD

Details

First Published September 24, 2010 in the journal Inflammatory Bowel Diseases,
Inflamm Bowel Dis. 2011 Jun;17(6):1359-72. doi: 10.1002/ibd.21478.
Epub 2010 Sep 24. PubMed PMID: 20872834; PubMed Central PMCID:PMC3026862
Read the full article (free) online at IBD (Oxford Academic) read or download as a PDF or online at PMC NIH

Abstract

BACKGROUND: Attenuated innate immune responses to the intestinal microbiota have been linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed that ...