Treatments for Inflammation Publications
Simon A. Hirota, PhD, Jeffrey Ng, MSc, Alan Lueng, Maitham Khajah, PhD, Ken Parhar, MD, Yan Li, MSc, Victor Lam, BSc, Mireille S. Potentier, Kelvin Ng, Misha Bawa, BSc, Donna-Marie McCafferty, PhD, Kevin P. Rioux, MD, PhD, Subrata Ghosh, MD, Ramnik J. Xavier, MD, Sean P. Colgan, PhD, Jurg Tschopp, PhD, Daniel Muruve, MD, Justin A. MacDonald, PhD, Paul L. Beck, MD, PhD
BACKGROUND: Attenuated innate immune responses to the intestinal microbiota have been linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed that ...
Inflammation significantly contributes to the progression of chronic kidney disease (CKD). Inflammasome-dependent cytokines, such as IL-1β and IL-18, play a role in CKD, but their regulation during renal injury is unknown. Here, we analyzed the processing of caspase-1, IL-1β, and IL-18 after unilateral ureteral obstruction (UUO) in mice, which suggested activation of the Nlrp3 inflammasome during renal injury. Compared with wild-type mice, Nlrp3(-/-) ...
Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome
Jeffrey Ng 1, Simon A Hirota, Olaf Gross, Yan Li, Annegret Ulke-Lemee, Mireille S Potentier, L Patrick Schenck, Akosua Vilaysane, Mark E Seamone, Hanping Feng, Glen D Armstrong, Jurg Tschopp, Justin A Macdonald, Daniel A Muruve, Paul L Beck
BACKGROUND & AIMS: Clostridium difficile-associated disease (CDAD) is the leading cause of nosocomial diarrhea in the United States. C difficile toxins TcdA and TcdB breach the intestinal barrier and trigger mucosal inflammation and intestinal damage. The inflammasome is an intracellular danger sensor of the innate immune system. In the present study, we hypothesize that TcdA and TcdB trigger inflammasome-dependent interleukin (IL)-1beta ...