Authors

Saurav Roy Choudhury, Liane Babes, Jennifer J. Rahn, Bo-Young Ahn, Kimberly-Ann R. Goring, Jennifer C. King, Arthur Lau, Björn Petri, Xiaoguang Hao, Andrew K. Chojnacki, Ajitha Thanabalasuriar, Erin F. McAvoy, Sébastien Tabariès, Christoph Schraeder, Kamala D. Patel, Peter M. Siegel, Karen A. Kopciuk, David C. Schriemer, Daniel A. Muruve, Margaret M. Kelly, Bryan G. Yipp, Paul Kubes, Stephen M. Robbins, Donna L. Senger

Details

Published in the journal Cell, Volume 178, Issue 5, Pg1205-1221.E17, August 22, 2019
DOI: https://doi.org/10.1016/j.cell.2019.07.017
Read the full publication online at Cell or view the PDF version

Highlights

• Dipeptidase 1 (DPEP1) serves as a vascular adhesion molecule in lungs and liver
• DPEP1 acts as a physical adhesion receptor independent of its dipeptidase activity
• Targeting DPEP1 reduces mortality in murine models of sepsis

Abstract

A hallmark feature of inflammation is the orchestrated recruitment ...

Authors

Arthur Lau, Hyunjae Chung, Takanori Komada, Jaye M. Platnich, Christina F. Sandall, Saurav Roy Choudhury, Justin Chun, Victor Naumenko, Bas G.J. Surewaard, Michelle C. Nelson, Annegret Ulke-Lemée, Paul L. Beck, Hallgrimur Benediktsson, Anthony M. Jevnikar, Sarah L. Snelgrove, Michael J. Hickey, Donna L. Senger, Matthew T. James, Justin A. Macdonald, Paul Kubes, Craig N. Jenne, Daniel A. Muruve

Details

Published in JCI, The Journal of Clinical Investigation, June 4, 2018
J Clin Invest. 2018 Jul 2;128(7):2894-2913. doi: 10.1172/JCI96640. Epub 2018 Jun 4.
Read the article online at JCI read the PDF version (JCI) – also available from the NIH PMC

Abstract

Radiographic contrast agents cause acute kidney injury (AKI), yet the underlying pathogenesis is poorly understood. Nod-like receptor pyrin containing 3–deficient (Nlrp3-deficient) mice displayed reduced epithelial cell injury and inflammation in the kidney in a model of contrast-induced AKI ...

Authors

Noah Muruve, Yuanchao Feng, Jaye Platnich, Daniel Hassett, Randall Irvin, Daniel Muruve, Frank Cheng

Details

Journal of Biomaterials Applications, first published February 21, 2017
2017 Mar;31(8):1225-1234. doi: 10.1177/0885328217692949. Epub 2017 Jan 1
Read the abstract, or access the journal here

Abstract

Titanium alloys are common materials in the manufacturing of dental and orthopedic implants. Although these materials exhibit excellent biocompatibility, corrosion in response to biological fluids can impact prosthesis performance and longevity. In this work, a PEGylated metal binding peptide (D-K122-4-PEG), derived from bacteria Pseudomonas aeruginosa, was applied on a titanium (Ti) alloy, and the corrosion resistance of the coated alloy specimen was investigated in simulated chloride-containing physiological fluids by electrochemical impedance spectroscopy and micro-electrochemical measurements, surface characterization, and biocompatibility testing. Compared to uncoated specimen, the D-K122-4-PEG-coated Ti alloy demonstrates decreased corrosion current density without affecting the natural passivity. Morphological ...