Treating organ inflammation

LSALT peptide (Metablok) is designed to target acute organ inflammation in the lungs, liver and kidneys.

Targeting Toxin Related AKI

Cilastatin is a major commercial drug candidate suited to preventing Acute Kidney Injury

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The Company

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Arch Biopartners Science

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Developing new drugs to prevent organ inflammation and injury

Arch is the leader in developing peptides, antibodies and small molecules that target organ inflammation caused by the enzyme Dipeptidase-1 (DPEP1).

Organ inflammation is a frequent cause of common injuries and disease with no effective treatments in the market today.

Arch is building a therapeutic drug platform of new candidates led by LSALT peptide targeting inflammation in the kidneys, lungs and liver, via the dipeptidase-1 (DPEP1) pathway.

Arch Biopartners Approach

The company has a long history of working closely with the scientific community, universities and research institutions. Arch Biopartners mission is to advance and build the value of select therapeutic innovations, develop the most promising intellectual property, and create value for its investors.

Find out more about the Company, our focus and the fundamentals that make Arch unique.

Arch Biopartners Arranges Non-Brokered Private Placement

TORONTO, Oct. 15, 2024 (GLOBE NEWSWIRE) -- Arch Biopartners Inc. (“Arch” or the “Company”) (TSX Venture: ARCH and OTCQB: ACHFF) today announced it has arranged a non-brokered private placement offering of 290,323 common shares priced at $1.55 per common share (the “Common Shares”) for gross proceeds of $450,000 CAD (the “Offering”). The proceeds of the Offering will be used by Arch as general working capital and for certain research expenses that are not covered by the Company’s existing funding grants. The Offering closed on ...

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Closes Units for Debt Settlement

TORONTO, Oct. 03, 2024 (GLOBE NEWSWIRE) -- Arch Biopartners Inc., (“Arch” or the “Company”) (TSX Venture: ARCH and OTCQB: ACHFF) announced today that the Company has closed a transaction that was previously announced on September 26, 2024 to settle an aggregate total of $2,600,000 of principal plus accrued interest of $130,000 on four deferred convertible notes maturing on Sept 30, 2024 (the “Notes”). The original terms of the four Notes included settlement of the principal owing with 3,220,147 common shares priced at a weighted ...

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Latest Scientific Publications

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New Drugs to Treat and Prevent Organ Inflammation Injury

Arch Biopartners key technologies, scientists, publications and ongoing trials.

LSALT peptide (Metablok), is the company’s lead drug candidate targeting organ inflammation in the lungs, liver and kidneys.

LSALT peptide trials and development

In 2024, the company is sponsoring a Phase II international multi-center, randomized, double-blind, placebo-controlled study of LSALT peptide targeting cardiac surgery-associated acute kidney injury (CS-AKI). Drug approval for treating CS-AKI may enable off-label use for other indications such as lung or liver inflammation injury, other AKI indications and septic shock.

The CS-AKI trial began dosing patients in March 2024. The trial began with five active hospital sites in Turkey, with three hospital sites announced in Canada (pending activation). The complete study is planned to include up to 240 patients in Turkey, Canada and the United States.

March 2024, dosing of first patient in Turkey marking the commencement of the Phase II CS-AKI trial.
March 2024, announcement of first Canadian site to join the trial, beginning with the University of Calgary, Cumming School of Medicine.
March 2024, publication of previous Phase II trial results targeting DPEP1 mediated lung inflammation provides further scientific rationale to advance LSALT peptide to prevent leukocyte recruitment and organ inflammation injury for other indications.
April 2024, announcement of St Michael’s Hospital and Toronto General Hospital (UHN) joining the trial.

Find out more about our science platforms and about LSALT peptide clinical trials and development targeting the treatment and prevention of common injuries and diseases related to organ inflammation.

Cilastatin is Arch’s second drug asset targeting acute kidney injury (AKI)

a DPEP1 inhibitor suited to preventing AKI caused by toxins

In 2024, the company announced that it is repurposing cilastatin and working with research and clinical collaborators to develop the drug as a new treatment to prevent toxin-related AKI.

Cilastatin was originally developed in the early 1980s by Merck Sharp & Dohme Research Laboratories to limit DPEP1’s role in the breakdown of imipenem, a β-lactam antibiotic used for the treatment of systemic infections. Now off patent, Arch is producing cilastatin to be approved for the first time as a standalone drug product.

Arch has method-of-use patents for cilastatin as a treatment to prevent kidney injury – currently issued or pending
Cilastatin is particularly well suited to prevent AKI caused by drug toxins due to its unique off-target effects that block toxin uptake into the kidney tissue
In August 2024, Arch announced that the company is participating in the PONTIAC phase II trial targeting acute kidney injury caused by drug toxins

AKI reflects a broad spectrum of clinical presentations ranging from mild injury to severe injury that may result in permanent and complete loss of renal function. Clinically, the causes of AKI include sepsis, ischemia-reperfusion injury, and various endogenous as well as exogenous (drug) toxins. There is no specific therapeutic treatment available in the market today that prevents AKI. In the worst cases, the kidneys fail, requiring dialysis or kidney transplantation for patient survival.

Patents for imipenem and cilastatin have expired and the combination drug is currently in a generic phase. There is no commercial history of cilastatin as a stand-alone drug product.

An experienced group of scientists working together to develop the Arch science platforms.

Science and Research Teams

Current work on LSALT peptide and Cilastatin is directed by Arch’s larger Treatments for Inflammation Team, led by Dr. Daniel Muruve (Arch Biopartners CSO), Dr. Justin Macdonald Ph. D., and Dr. Arthur Lau Ph. D (Arch Biopartners Project Director), who are primarily based at the University of Calgary. Dr. David Luke, BScPhm, PharmD, is a Strategic Advisor and Senior Clinical Lead working to support the Board of Directors and the company’s ongoing clinical trials with LSALT peptide.
The DPEP1 Inflammation Pathway and LSALT Peptide (Metablok) were discovered by the Metablok team – Dr. Stephen Robbins Ph. D., Dr. Donna Senger Ph. D., Jennifer Rahn B Sc., M Sc. and their colleague Dr. Paul Kubes at the University of Calgary.

The Arch Biopartners Science Teams have all participated and authored key papers and journal publications as a core part of their ongoing scientific research, discoveries and development.

Treatments for Inflammation publications surrounding the development of LSALT Peptide (Metablok) as a treatment for inflammation with broad application to prevent organ and tissue injury
AB569 publications describing AB569 as a novel bactericidal treatment for treatment resistant bacteria and Respiratory Pseudomonas
BORG Peptide publications discussing a peptide-based biological coating for enhanced corrosion resistance, strength and control of adhesion of bacteria and microbes.
Brain Tumor Stem Cell Targeting publications describe the development of a peptide-based delivery platform for targeting malignant brain tumors