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Arch Biopartners Initiates Manufacturing Process for Metablok

TORONTO, ONTARIO--(Marketwired - Oct. 10, 2017) - Arch Biopartners, Inc., (Arch or the Company) (TSX VENTURE:ARCH)(OTCBB:ACHFF) a portfolio-based biotechnology company, today announced it has engaged CSBio in Menlo Park, California, to begin the manufacturing process for Metablok, the Company's drug candidate for treating inflammation, cancer metastasis and sepsis.

Arch is planning a Phase I human trial to evaluate Metablok's safety and pharmacokinetic profile. The phase I study will be followed by Phase II clinical trials to evaluate the efficacy of Metablok in preventing cardiac surgery-associated acute kidney injury.

In pre-clinical studies, Arch scientists have demonstrated Metablok's ability to prevent acute kidney injury by blocking the inflammatory response triggered by kidney ischemia/reperfusion. Currently, there are no specific or effective treatments to prevent acute kidney injury.

An investigational new drug (IND) application to the U.S. Food and Drug Administration (FDA) is currently being prepared by the Metablok team for submission in 2018.

"Acute kidney injury following cardiac surgery is a serious complication that is associated with an increased risk of death and other adverse effects. Advancing the pre-clinical development to prepare Metablok for a human trial is an exciting development for our drug that we believe will have a major clinical impact in patients at risk of acute kidney injury," said Dr. Daniel Muruve, Chief Science Officer of Arch, Professor of Medicine and Chief of Nephrology at the University of Calgary.

CSBio is currently producing Metablok under good laboratory practice ("GLP") standards to enable toxicology and pharmacology studies needed to support a pre-IND submission meeting and subsequent IND application with the FDA.

Notes for Editors

About Metablok

Metablok is a novel peptide drug candidate in the Arch development pipeline and a potential treatment for inflammation, sepsis and cancer metastasis.

Inflammation and Acute Kidney Injury

Inflammation is a localized physical condition that involves the activation of the immune system in response to infection, tissue injury, or autoimmunity. Inflammation is involved in the pathogenesis of many diseases and plays a significant role in acute kidney injury. Acute kidney injury due to ischemia/reperfusion occurs in up to 40% of patients undergoing cardiovascular and other major surgeries.

Sepsis:

Sepsis and cancer metastasis represent large unmet medical needs in the world today. Sepsis alone occurs in 1 to 2% of all hospitalizations in the US. It affects at least 700,000 individuals per year.

Sepsis is a serious illness caused by the body's immune response to an infection. White blood cells, or leukocytes, defend the body against toxins and infection. If the immune system activates too many white blood cells to fight the infection, there is a risk of widespread, life threatening inflammation termed "Sepsis".

Sepsis is known to cause organ damage. Blood clotting during sepsis inhibits blood flow to organs and thus reduces their intake of nutrients and oxygen. In severe cases, one or more organs fail. In the worst cases, infection leads to a dangerous drop in blood pressure, called septic shock. This can quickly lead to the failure of several organs such as lungs, kidneys and liver, causing death.

Permanent organ damage can occur in patients who survive sepsis. Under current standard of care, mortality rates are over 20% for sepsis and over 50% for septic shock.

Cancer Metastasis:

Cancer is a life threatening disease because of its ability to spread from its original tumour site to other tissues and organs in the body. This process of metastasis occurs through the bloodstream or lymphatic system.

Metastasis is of great importance since most of the cancer deaths are caused by spread of the primary cancer to other sites in the body. Recent evidence shows that 60% to 70% of cancer patients have started the metastatic process by the time of diagnosis. Additionally, patients that do not have tumor spread at diagnosis are at risk for metastatic disease. New therapeutic treatments that protect patients against metastasis would be a major breakthrough in the treatment of cancer.

About CS Bio:

CSBio is a leading peptide and peptide synthesizer manufacturing company located on the edge of Silicon Valley in Menlo Park, California. Since 1993, CSBio has been providing high quality custom peptides, cGMP peptides and automated peptide synthesizers to the global biotech community. CSBio's peptide products and peptide synthesis equipment can be found in peptide production laboratories and pharmaceutical companies worldwide.

About Arch Biopartners

Arch Biopartners Inc. is focused on the development of innovative technologies that have the potential to make a significant medical or commercial impact. Arch works closely with the scientific community, universities and research institutions to advance and build the value of select preclinical technologies, develop the most promising intellectual property, and create value for its investors.

Arch has established a diverse portfolio that includes AB569, a potential new treatment for antibiotic resistant bacterial infections; Metablok, a potential treatment for inflammation, sepsis and cancer metastasis; MetaMx, which targets elusive brain tumor initiating cells; and, 'Borg' peptide coatings that increase corrosion resistance and decrease biofilm on various medical grade metals and plastics.

For more information on Arch Biopartners, other public documents Arch has filed on SEDAR and its technologies including, please visit www.archbiopartners.com

The Company has 55,299,679 common shares outstanding.

Forward-Looking Statements

All statements, other than statements of historical fact, in this news release are forward looking statements that involve various risks and uncertainties, including, without limitation, statements regarding the future plans and objectives of the Company. There can be no assurance that such statements will prove to be accurate. Actual results and future events could differ materially from those anticipated in such statements. These and all subsequent written and oral forward-looking statements are based on the estimates and opinions of management on the dates they are made and are expressly qualified in their entirety by this notice. The Company assumes no obligation to update forward-looking statements should circumstances or management's estimates or opinions change.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Releases 2018
December 11th 2018

Arch Biopartners Forms New Subsidiary to Pursue a Phase I Trial in Australia for Metablok (LSALT Peptide)

October 29th 2018

Arch Biopartners Provides Toxicology Update for Metablok

September 26th 2018

Arch Biopartners Announces Completion of GMP Manufacturing of Metablok Vials

August 14th 2018

Arch Biopartners Engages Dalton Pharma Services for GMP Manufacturing of Metablok

June 26th 2018

Arch Biopartners Receives $332,750 From the Exercise of Warrants

June 19th 2018

Arch Biopartners to Seek Regulatory Guidance From the U.S FDA for AB569

May 22nd 2018

Arch Biopartners Engages Nucro-Technics To Complete Toxicology Studies To Support Investigational New Drug Application For Metablok

May 16th 2018

Arch Biopartners Announces Listing on OTCQB Exchange

May 8th 2018

Arch Biopartners Completes Pre-IND Meeting with U.S. FDA on LSALT Peptide for Preventing Acute Kidney Injury in Cardiac Surgery Patients

March 27th 2018

Arch Biopartners Announces Issuance of U.S. Patent for Its Novel Antibacterial Drug AB569, Designed to Target Chronic Infection and Antibiotic Resistance

March 21st 2018

Arch Biopartners Granted Pre-Ind Meeting With FDA for Candidate Drug to Prevent Acute Kidney Injury

March 9th 2018

Arch Biopartners Closes $1.25M Non-Brokered Private Placement Financing

February 27th 2018

Arch Biopartners Announces Start of GMP Manufacturing for Metablok at CSBio

February 13th 2018

Arch Biopartners Announces AB569 Phase I Human Trial Begins Patient Recruitment and Enrollment Stage

Press Releases 2017
December 6th 2017

Arch Biopartners Announces Completion of GMP Manufacturing of AB569 and Start Date of Phase I Trial

November 1st 2017

Arch Biopartners Engages Nucro Technics to Begin Toxicology Studies for Metablok

October 10th 2017

Arch Biopartners Initiates Manufacturing Process for Metablok

September 28th 2017

Arch Biopartners' GMP Manufacturing of AB569 Progresses to Final Production Stage

September 12th 2017

Arch Biopartners Increases Non-Brokered Private Placement Financing

July 27th 2017

Arch Biopartners Provides Update on GMP Manufacturing of AB569

July 24th 2017

Arch Biopartners Retains Market Maker and Arranges Non Brokered Private Placement Financing

May 4th 2017

Arch Biopartners Announces Start of GMP Manufacturing for AB569 at Dalton Pharma Services

April 18th 2017

Grant of Options to Directors, Officers and Scientists

April 13th 2017

Arch Biopartners' Lead Anti-Bacterial Drug Candidate AB569 to Enter Investigator-Sponsored Phase I Human Trial

February 28th 2017

Arch Biopartners Closes Non-Brokered Private Placement Financing

February 23rd 2017

Arch Biopartners Announces TSXV Stock Ticker Symbol Change to "ARCH"

February 21st 2017

Arch Biopartners Announces Non-Brokered Private Placement Financing

Press Releases 2016
December 12th 2016

Arch Biopartners Appoints Patrick Vink to Board of Directors

October 27th 2016

Arch Biopartners Collaborates With Team at Cincinnati Veterans Affairs Medical Center to Prepare Phase I and II Human Trial Protocol and Application for AB569

October 11th 2016

Arch Biopartners Announces Issuance of U.S. Patent for Metablok

August 10th 2016

Arch Biopartners Engages Catalent to Begin Manufacturing Process for AB569

July 18th 2016

Arch Biopartners Forms Clinical and Medical Advisory Board for AB569

July 5th 2016

Arch "Borg" Peptide Coating Displays Anti Corrosion Performance on Stainless Steel

June 1st 2016

Arch Biopartners' AB569 Receives Final Approval from European Commission for Orphan Designation for Cystic Fibrosis

April 26th 2016

Arch Biopartners' AB569 Receives Positive Opinion from EMA COMP for Orphan Designation for Cystic Fibrosis

March 16th 2016

Arch Biopartners Enters Exclusive License Agreement With University of Cincinnati for AB569

March 1st 2016

Arch Scientists Publish Data on the Efficacy and Mechanism of Action of Lead Drug Candidate AB569

February 3rd 2016

Arch Biopartners Submits Orphan Drug Application for AB569 to European Medicines Agency

January 6th 2016

Arch Biopartners, McMaster Scientists, Expand MetaMx Collaboration with Mitacs Award

Press Releases 2015
December 1st 2015

Arch Biopartners Provides MetaMx Development Update

November 13th 2015

Arch Biopartners Receives Orphan Drug Designation from FDA for AB569

October 21st 2015

Arch Biopartners Retains Virtus Advisory to Provide Investor Relations Services

September 17th 2015

Arch Biopartners: AB569 Successfully Completes Pre-Clinical Validation Studies

August 5th 2015

Arch Biopartners Announces Issuance of U.S. Patent for Brain Tumor Targeting Peptides

August 4th 2015

Arch Biopartners Announces Issuance of a Second U.S. Patent for Peptide Solid Surface Interface

July 23rd 2015

Arch Scientists Use 'BORG' Peptides to Improve Biocompatibilty of Polysulfone for Use in Dialysis

June 8th 2015

Dr. Sheila Singh, MD PhD. Joins Arch Biopartners as Medical and Clincial Advisor

April 1st 2015

Arch Biopartners 2015 AGM Results and Technology Status Update

March 18th 2015

Arch Biopartners Identifies Candidate Drug to Treat Psuedomonas Respiratory Infections

February 25th 2015

Arch Biopartners Announces Issuance of U.S. Patent for Peptide Solid Surface Interface

February 19th 2015

Arch Biopartners Receives Final Approval to List on TSX Venture Exchange

January 26th 2015

Arch Biopartners Completes Private Placement

January 16th 2015

Arch Biopartners Receives Conditional Approval for Listing on TSXV

January 6th 2015

Arch Biopartners Announces Private Placement

Press Releases 2014
November 26th 2014

Arch Biopartners Completes Clinical Development Plan for MetaMx

October 15th 2014

Arch Biopartners Introduces Metablok, a Novel Therapeutic Candidate for Blocking Sepsis, Cancer Metastasis

August 21st 2014

Arch Biopartners Appoints Adrian Haigh to Board of Directors

May 29th 2014

Arch Biopartners Hires d3 Medicine to Develop a Human Trial for Brain Tumor Targeting Technology

April 17th 2014

Arch Biopartners Appoints Claude Allary to Board of Directors

March 28th 2014

Arch Biopartners Enters Option to License University of Cincinnati Patent for Treating Bacterial Respiratory Infections

March 12th 2014

Arch Biopartners Announcement

February 25th 2014

Arch Biopartners Completes Private Placement and Receives NRC Funding

Press Releases 2013
November 20th 2013

Brain Tumor Cell Targeting Technology: Data to Be Presented at the Society of Neuro-Oncology Quadrennial Meeting

September 17th 2013

Arch Biopartners Appoints Former Roche Executives Patrick Smith and Craig Rayner as Drug Development Advisors

September 12th 2013

Arch Biopartners Announces Issuance of U.S. Patent for Brain Tumor Cell Targeting Technology

August 14th 2013

Arch Biopartners Joins the Life Sciences Canadian Technology Accelerator in San Francisco

June 6th 2013

Arch Biopartners Announces Issuance of Additional U.S. Patent for Biofilm Inhibitor

April 22nd 2013

Brain Tumour Targeting Team Awarded Additional Funding

April 3rd 2013

Arch Scientists Publish Data Linking Inflammatory Enzymes to Inflammatory Bowel Disease

April 1st 2013

Arch Biopartners Announces Shareholder Approval to Allow Listing to Move to New Exchange

Press Releases 2012
December 7th 2012

Arch Scientists Publish New Stainless Steel Anti Corrosion and Biofilm Data

October 18th 2012

Dr. Julia Liu to Present at American College of Gastroenterology Annual Meeting Oct 22, 2012

September 6th 2012

Arch Biopartners Enters Option to Acquire Irritable Bowel Syndrome Diagnostic Technology

August 21st 2012

Arch Scientists Successfully Image Brain Tumour Initiating Cells Using MRI

March 15th 2012

Arch Awarded Funding from the Government of Canada to Develop Brain Tumour Targeting Technology

February 28th 2012

Arch Scientists to Lead Anti Corrosion Project for Auto Industry

January 24th 2012

Arch Biopartners Appoints Claude Allary as Special Advisor

Press Releases 2011
December 19th 2011

Arch Scientists Inhibit Biofilm Formation and Increase Hardness on Titantium

November 7th 2011

Arch Biopartners Engages Intertek Cantox to Devise Drug Development Plan for Lead Cancer Compound

September 7th 2011

Arch Biopartners Identify Lead Compound for Pancreatic Cancer and Non Small Cell Lung Cancer

July 18th 2011

Arch Biopartners Hires Investor Relations Firm

July 14th 2011

Arch Biopartners Announces Issuance of New U.S. Patent for Biofilm Inhibitor

July 6th 2011

Arch Biopartners, U of Calgary Extend Agreement

June 27th 2011

Arch Biopartners Enters Agreement to Develop Prototype Diagnostic Imaging Agents for Brain Tumor Stem Cells

June 23rd 2011

Arch Biopartners Scientists Awarded Funding to Further Develop Brain Tumour Targeting Technology

May 24th 2011

Arch Scientists to Present at ESF-LFUI Conference in Austria

May 10th 2011

Arch Scientists Create New Bio-Organic Metal That Is Harder, Resists Corrosion

April 11th 2011

Arch Cancer Therapeutics' Technology Update

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Arch Biopartners
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Contact us
+1 647 428 7031
info@archbiopartners.com
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M5V 1M1 Canada
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Press Releases
  • Home
  • About us
  • Our Science
    • Our Key Platforms
      • MetaBlok™
      • AB569
      • BORG
      • MetaMx™
    • Our Publications
      • AB569
      • Brain Tumor Stem Cell Targeting
      • BORG Peptide Solid Surface Interface
      • Treatments for Inflammation
  • Our Team
    • Our Management
    • Our Principal Scientists
      • MetaBlok™ and MetaMx™
      • AB569 & Respiratory Pseudomonas
      • BORG Peptide
      • Treatments for Inflammation
  • Investor Hub
    • Fundamentals
      • Press Releases
      • Investor Information
      • Stock Performance
    • Reports and Filings
      • Management Discussion and Analysis
      • Annual and Quarterly Reports
      • Proxies and Information Circulars
      • Material Change Documents
      • Other SEDAR Filings
  • Contact Us