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Many patients seeking medical care are afflicted with non-infectious chronic diseases. Common chronic diseases include chronic heart failure, chronic kidney failure, osteoarthritis and inflammatory bowel disease. Patients who have these illnesses often experience a progressive course of disease for which there are few curative treatments available. At the root of all these illnesses lies a component of inflammation that is non-infectious and thus defined as ‘sterile inflammation.’
Recently, Arch scientists have identified specific molecular pathways that cause sterile inflammation. In proof-of-principle studies, Arch scientists have confirmed that these sterile inflammatory pathways are involved in chronic kidney disease and inflammatory bowel disease.
The primary objective of this research program is to develop novel drugs that target molecular pathways involved in sterile inflammation.
First generation anti-inflammatory molecules (drugs) have been designed and synthesized by the AI team. These compounds will begin testing in proprietary inflammation disease models during the first half of 2011.
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