Widespread application for the treatment of chronic diseases
As the population ages, the prevalence of chronic disease is on the rise and includes common conditions such as heart disease, diabetes, arthritis, inflammatory/infectious bowel disease and chronic kidney disease. The overall objective is to develop new diagnostic tests or anti-inflammatory drugs that can be used to treat humans with these common chronic diseases.
Inflammation plays a role in the pathogenesis of almost all acute and chronic diseases, and common inflammation pathways underlie these diseases regardless of the tissue affected. Furthermore, inflammation in one organ can have systemic effects and disrupt distant physiologic sites. Inflammation is also an important aspect of healing, playing a key role in resolving disease and promoting restitution of injured tissues. Inflammation therefore is an important therapeutic target for many common chronic diseases that affect a large portion of the population.
Arch is performing leading edge science to identify inflammatory pathways and molecular targets of the immune system that cause unresolved acute inflammation and promote the development of chronic inflammatory disorders. Diseases under study include chronic kidney disease, chronic heart disease (failure), inflammatory bowel disease and Clostridium difficile colitis (one of the most common and serious types of hospital-acquired infection). Molecular targets identified in disease models are being translated to develop small molecule drugs that block these inflammatory pathways. Methods to adapt basic science discoveries to diagnostic tests in humans are also under way.