MetaMx™ is composed of novel, synthetic peptides that target and attach to BTICs and invasive glioma cells, for the purpose of imaging, diagnosis and developing targeted therapies to improve patient outcomes and survival rates among glioblastoma patients.
MetaBlok is a new drug candidate and potential treatment for inflammation, sepsis and cancer metastasis.
Arch is currently pursuing clinical development of Metablok to prevent acute kidney injury caused by inflammation and expects to make additional disclosures as milestones toward a human trial are completed. Arch believes Metablok has the potential to be a major breakthrough in the treatment of diseases where inflammation plays a major role, as well as in sepsis and cancer metastasis.
MetaBlok was invented by Arch scientists Dr. Stephen Robbins, Dr. Donna Senger, Dr. Jennifer Rahn and their University of Calgary colleague, Dr. Paul Kubes. The inventors have assigned the Metablok intellectual property to the Company.
AB569: Treatment for Drug Resistant Bacterial Infections
AB569 is a new drug candidate for treating antibiotic resistant bacterial infections, primarily in the lungs and urinary tract. It also has potential to be modified for use in other indications, including adaptation as a topical cream for bacterial skin infections.
AB569 has a mechanism of action that differs from the mechanism of action of antibiotics. AB569 has orphan drug status in the U.S. for the treatment of Pseudomonas aeruginosa infections in the respiratory tracts of patients with cystic fibrosis. AB569 has orphan medicinal product designation in Europe for the treatment of cystic fibrosis.
Arch has developed a group of novel synthetic peptides and peptide conjugates that employ a novel chemistry (non-toxic, and environmentally friendly process) to react with solid surfaces such as metals, and plastics to generate new materials that display new surface properties.
Widespread application for the treatment of chronic diseases
As the population ages, the prevalence of chronic disease is on the rise and includes common conditions such as heart disease, diabetes, arthritis, inflammatory/infectious bowel disease and chronic kidney disease. The overall objective is to develop new diagnostic tests or anti-inflammatory drugs that can be used to treat humans with these common chronic diseases.