TSXV:ARCH
  • Home
  • About usOur story, our approach
  • Our Science Pipeline, research & publications
    • Our Key Platforms
      • AB569Treatment for Respiratory Pseudomonas aeruginosa Infections
      • MetaMx™Brain Tumor Initiating Cell Targeting
      • MetaBlok™Blocking sepsis, inflammation and cancer metastasis
      • BORGPeptide Solid Surface Interface
      • Treatments for InflammationWidespread application for the treatment of chronic diseases.
    • Our PublicationsPeer-reviewed scientific publications
      • AB569
      • Brain Tumor Stem Cell Targeting
      • BORG Peptide Solid Surface Interface
      • Treatments for Inflammation
  • Our Team Management & lead scientists
    • Our ManagementGovernance, Executive, Board of Directors and Advisors
    • Our Principal ScientistsLearn about the scientists behind our technologies
      • Treatments for Inflammation
      • BORG Peptide
      • AB569 & Respiratory Pseudomonas
      • MetaBlok™ and MetaMx™
  • Investor Hub Investor relations, fundamentals
    • Fundamentals
      • Press Releases
      • Investor Information
      • Stock Performance
    • Reports and Filings
      • Management Discussion and Analysis
      • Annual and Quarterly Reports
      • Proxies and Information Circulars
      • Material Change Documents
      • Other SEDAR Filings
  • Contact Us

Arch Biopartners Announces Issuance of U.S. Patent for Its Novel Antibacterial Drug AB569, Designed to Target Chronic Infection and Antibiotic Resistance

TORONTO, March 27, 2018 (GLOBE NEWSWIRE) -- Arch Biopartners Inc., (Arch or the Company) (TSX Venture:ARCH) (OTCBB:ACHFF), announced today that the U.S. Patent and Trademark Office has issued U.S. Patent 9,925,206 protecting the composition and methods of use of its lead anti-bacterial drug candidate, AB569.

The new U.S. patent is titled, “Compositions and Methods for Treating Bacterial Infection” and has been issued to the University of Cincinnati, which previously granted an exclusive commercial license to Arch on all patents related to AB569.

The sole inventor of the patent is Dr. Daniel Hassett PhD, a Professor at the University of Cincinnati College Of Medicine in the Department of Molecular Genetics, Biochemistry and Microbiology. He is also a Principal Scientist at Arch.

AB569 employs a completely new approach to the problem of chronic bacterial infection and antibiotic resistance. “AB569 has two active ingredients that produce a dramatic and synergistic effect at killing many antibiotic resistant bacteria including Pseudomonas aeruginosa (P. aeruginosa), which commonly causes severe chronic infections in the lungs of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) patients. AB569 has the potential to make a significant medical impact on treating infection where traditional antibiotics fail,” said Dr. Hassett.

“This patent issuance, which protects the composition of AB569, gives Arch a stronger commercial position to pursue treating not just CF patients, but also the millions of other patients that have chronic antibiotic resistant lung infections including those with COPD. It also opens the door for Arch to develop treatments for many other indications where antibiotic resistance is a problem, such as urinary tract infections and wound care,” said Richard Muruve, CEO of Arch.

Worldwide, there are over 251 million people afflicted with COPD and over 70,000 people with CF. Arch received orphan drug designation for AB569 (active ingredients sodium nitrite and EDTA) from the U.S. Food and Drug Administration (FDA) for the treatment of CF patients with P. aeruginosa infections. Arch also received an orphan medicinal product designation for AB569 from the European Medicines Agency (EMA) for the general treatment of CF.

Bacterial infections cause approximately 50% of the acute exacerbations in COPD patients. AB569 is a candidate to treat bacterial respiratory infections caused by the most common pathogens found among COPD patients which include Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis, as well as treating P. aeruginosa infections which become the most prevalent in advanced COPD disease.

AB569 Phase I Investigator Initiated Trial

Cincinnati Veterans Affairs Medical Center (CVAMC) has started an investigator initiated Phase I human trial in up to twenty-five healthy volunteers to first evaluate the safety and pharmacokinetic profile of AB569. The first patients were recruited and enrolled in the trial in February.

Dr. Ralph Panos, Chief of Medicine at CVAMC and world-renowned COPD expert, is the lead investigator of the trial. Arch is funding the study, contributing the AB569 inhalation clinical drug kits and other materials to support the trial.

Dr. Panos’s clinical team is evaluating single administration of nebulized AB569 in each participant. The Phase I trial has been designed to determine the pharmacokinetic profile of plasma nitrite and nitrate metabolites, exhaled nitric oxide and circulating hemoglobin after a single inhalation of AB569. In addition, the trial also aims to determine the tolerance of nebulized AB569 in three escalating doses of acidified sodium nitrite and EDTA.

Following the successful completion of the Phase I study, the clinical team at CVAMC, in association with the University of Cincinnati College of Medicine, plans to transition the AB569 program into a Phase II trial to test the drug treatment’s efficacy in treating chronic lung infection caused by P. aeruginosa and other bacterial pathogens in COPD and/or CF patients.

About AB569 and antibiotic resistant airway infections in CF, COPD

AB569 is a bactericidal compound and constitutes an innovative potential treatment for dealing with pulmonary bacterial infection, which is a significant problem for patients with CF, COPD or ventilator associated pneumonia. In pre-clinical studies, AB569 has demonstrated significant ability to kill many types of Gram-negative and Gram-positive bacteria.

Antibiotics are increasingly being used to treat COPD and CF patients who have chronic bacterial respiratory infection. AB569 has the potential to be a treatment solution where antibiotic resistance strains are increasingly prevalent,since AB569 has a powerful bactericidal mechanism of action that differs from conventional antibiotics. In particular, AB569inhibitsDNA, protein and ATP synthesis, which are three vital constituents of the bacterial cell.

P. aeruginosa affects the majority of adult CF patients and often infects patients from childhood onward. CF patients are predisposed to bacterial lung infections due to abnormal mucus production in the lungs and airways. In particular, P. aeruginosa infects 40% of CF patients between the ages of 6 and 10 years of age. By the age of 17, the frequency of infection increases to ~50% and reaches approximately 60% of all CF patients between the ages of 25 and 34.

The mucoid form of P. aeruginosa is a very challenging infection to treat due to its high resistance to both conventional antibiotics and phagocyte–mediated killing. Once patients present with the mucoid form of P. aeruginosa, their overall lung function precipitously declines, resulting in a poor overall clinical prognosis.

Likewise, people with COPD have compromised innate immune systems and respiratory conditions that are vulnerable to chronic bacterial infections that are often resistant to conventional antibiotic regimens.

COPD is a major health problem worldwide and its prevalence is increasing, ranked by the World Health Organization as the third leading cause of death. COPD is a general term to describe progressive lung diseases which includes chronic bronchitis, emphysema, and non-reversible asthma. Most cases are caused by inhaling pollutants, predominantly from smoking or contaminated air in highly polluted cities or in the workplace.

About Arch Biopartners

Arch Biopartners Inc. is focused on the development of innovative technologies that have the potential to make a significant medical or commercial impact. Arch works closely with the scientific community, universities and research institutions to advance and build the value of select preclinical technologies, develop the most promising intellectual property, and create value for its investors.

Arch has established a diverse portfolio that includes AB569, a potential new treatment for antibiotic resistant bacterial infections; Metablok, a potential treatment for inflammation, sepsis and cancer metastasis; MetaMx, which targets elusive brain tumor initiating cells; and, ‘Borg’ peptide coatings that increase corrosion resistance and decrease biofilm on various medical grade metals and plastics.

For more information on Arch Biopartners, its technologies and other public documents Arch has filed on SEDAR, please visit www.archbiopartners.com

The Company has 57,799,679 common shares outstanding.

For more information, please contact:

Richard Muruve Chief Executive Officer Arch Biopartners, Inc. 647-428-7031 This email address is being protected from spambots. You need JavaScript enabled to view it.

Forward-Looking Statements

All statements, other than statements of historical fact, in this news release are forward looking statements that involve various risks and uncertainties, including, without limitation, statements regarding the future plans and objectives of the Company. There can be no assurance that such statements will prove to be accurate. Actual results and future events could differ materially from those anticipated in such statements. These and all subsequent written and oral forward-looking statements are based on the estimates and opinions of management on the dates they are made and are expressly qualified in their entirety by this notice. The Company assumes no obligation to update forward-looking statements should circumstances or management’s estimates or opinions change.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

PDF

Press Releases 2017
December 6th 2017

Arch Biopartners Announces Completion of GMP Manufacturing of AB569 and Start Date of Phase I Trial

November 1st 2017

Arch Biopartners Engages Nucro Technics to Begin Toxicology Studies for Metablok

October 24th 2017

Arch Biopartners Closes Convertible Note Financing

October 10th 2017

Arch Biopartners Initiates Manufacturing Process for Metablok

September 28th 2017

Arch Biopartners' GMP Manufacturing of AB569 Progresses to Final Production Stage

September 12th 2017

Arch Biopartners Increases Non-Brokered Private Placement Financing

July 27th 2017

Arch Biopartners Provides Update on GMP Manufacturing of AB569

July 24th 2017

Arch Biopartners Retains Market Maker and Arranges Non Brokered Private Placement Financing

May 4th 2017

Arch Biopartners Announces Start of GMP Manufacturing for AB569 at Dalton Pharma Services

April 18th 2017

Grant of Options to Directors, Officers and Scientists

April 13th 2017

Arch Biopartners' Lead Anti-Bacterial Drug Candidate AB569 to Enter Investigator-Sponsored Phase I Human Trial

February 28th 2017

Arch Biopartners Closes Non-Brokered Private Placement Financing

February 23rd 2017

Arch Biopartners Announces TSXV Stock Ticker Symbol Change to "ARCH"

February 21st 2017

Arch Biopartners Announces Non-Brokered Private Placement Financing

Press Releases 2016
December 12th 2016

Arch Biopartners Appoints Patrick Vink to Board of Directors

October 27th 2016

Arch Biopartners Collaborates With Team at Cincinnati Veterans Affairs Medical Center to Prepare Phase I and II Human Trial Protocol and Application for AB569

October 11th 2016

Arch Biopartners Announces Issuance of U.S. Patent for Metablok

August 10th 2016

Arch Biopartners Engages Catalent to Begin Manufacturing Process for AB569

July 18th 2016

Arch Biopartners Forms Clinical and Medical Advisory Board for AB569

July 5th 2016

Arch "Borg" Peptide Coating Displays Anti Corrosion Performance on Stainless Steel

June 1st 2016

Arch Biopartners' AB569 Receives Final Approval from European Commission for Orphan Designation for Cystic Fibrosis

April 26th 2016

Arch Biopartners' AB569 Receives Positive Opinion from EMA COMP for Orphan Designation for Cystic Fibrosis

March 16th 2016

Arch Biopartners Enters Exclusive License Agreement With University of Cincinnati for AB569

March 1st 2016

Arch Scientists Publish Data on the Efficacy and Mechanism of Action of Lead Drug Candidate AB569

February 3rd 2016

Arch Biopartners Submits Orphan Drug Application for AB569 to European Medicines Agency

January 6th 2016

Arch Biopartners, McMaster Scientists, Expand MetaMx Collaboration with Mitacs Award

Press Releases 2015
December 1st 2015

Arch Biopartners Provides MetaMx Development Update

November 13th 2015

Arch Biopartners Receives Orphan Drug Designation from FDA for AB569

October 21st 2015

Arch Biopartners Retains Virtus Advisory to Provide Investor Relations Services

September 17th 2015

Arch Biopartners: AB569 Successfully Completes Pre-Clinical Validation Studies

August 5th 2015

Arch Biopartners Announces Issuance of U.S. Patent for Brain Tumor Targeting Peptides

August 4th 2015

Arch Biopartners Announces Issuance of a Second U.S. Patent for Peptide Solid Surface Interface

July 23rd 2015

Arch Scientists Use 'BORG' Peptides to Improve Biocompatibilty of Polysulfone for Use in Dialysis

June 8th 2015

Dr. Sheila Singh, MD PhD. Joins Arch Biopartners as Medical and Clincial Advisor

April 1st 2015

Arch Biopartners 2015 AGM Results and Technology Status Update

March 18th 2015

Arch Biopartners Identifies Candidate Drug to Treat Psuedomonas Respiratory Infections

February 25th 2015

Arch Biopartners Announces Issuance of U.S. Patent for Peptide Solid Surface Interface

February 19th 2015

Arch Biopartners Receives Final Approval to List on TSX Venture Exchange

January 26th 2015

Arch Biopartners Completes Private Placement

January 16th 2015

Arch Biopartners Receives Conditional Approval for Listing on TSXV

January 6th 2015

Arch Biopartners Announces Private Placement

Press Releases 2014
November 26th 2014

Arch Biopartners Completes Clinical Development Plan for MetaMx

October 15th 2014

Arch Biopartners Introduces Metablok, a Novel Therapeutic Candidate for Blocking Sepsis, Cancer Metastasis

August 21st 2014

Arch Biopartners Appoints Adrian Haigh to Board of Directors

May 29th 2014

Arch Biopartners Hires d3 Medicine to Develop a Human Trial for Brain Tumor Targeting Technology

April 17th 2014

Arch Biopartners Appoints Claude Allary to Board of Directors

March 28th 2014

Arch Biopartners Enters Option to License University of Cincinnati Patent for Treating Bacterial Respiratory Infections

March 12th 2014

Arch Biopartners Announcement

February 25th 2014

Arch Biopartners Completes Private Placement and Receives NRC Funding

Press Releases 2013
November 20th 2013

Brain Tumor Cell Targeting Technology: Data to Be Presented at the Society of Neuro-Oncology Quadrennial Meeting

September 17th 2013

Arch Biopartners Appoints Former Roche Executives Patrick Smith and Craig Rayner as Drug Development Advisors

September 12th 2013

Arch Biopartners Announces Issuance of U.S. Patent for Brain Tumor Cell Targeting Technology

August 14th 2013

Arch Biopartners Joins the Life Sciences Canadian Technology Accelerator in San Francisco

June 6th 2013

Arch Biopartners Announces Issuance of Additional U.S. Patent for Biofilm Inhibitor

April 22nd 2013

Brain Tumour Targeting Team Awarded Additional Funding

April 3rd 2013

Arch Scientists Publish Data Linking Inflammatory Enzymes to Inflammatory Bowel Disease

April 1st 2013

Arch Biopartners Announces Shareholder Approval to Allow Listing to Move to New Exchange

Press Releases 2012
December 7th 2012

Arch Scientists Publish New Stainless Steel Anti Corrosion and Biofilm Data

October 18th 2012

Dr. Julia Liu to Present at American College of Gastroenterology Annual Meeting Oct 22, 2012

September 6th 2012

Arch Biopartners Enters Option to Acquire Irritable Bowel Syndrome Diagnostic Technology

August 21st 2012

Arch Scientists Successfully Image Brain Tumour Initiating Cells Using MRI

March 15th 2012

Arch Awarded Funding from the Government of Canada to Develop Brain Tumour Targeting Technology

February 28th 2012

Arch Scientists to Lead Anti Corrosion Project for Auto Industry

January 24th 2012

Arch Biopartners Appoints Claude Allary as Special Advisor

Press Releases 2011
December 19th 2011

Arch Scientists Inhibit Biofilm Formation and Increase Hardness on Titantium

November 7th 2011

Arch Biopartners Engages Intertek Cantox to Devise Drug Development Plan for Lead Cancer Compound

September 7th 2011

Arch Biopartners Identify Lead Compound for Pancreatic Cancer and Non Small Cell Lung Cancer

July 18th 2011

Arch Biopartners Hires Investor Relations Firm

July 14th 2011

Arch Biopartners Announces Issuance of New U.S. Patent for Biofilm Inhibitor

July 6th 2011

Arch Biopartners, U of Calgary Extend Agreement

June 27th 2011

Arch Biopartners Enters Agreement to Develop Prototype Diagnostic Imaging Agents for Brain Tumor Stem Cells

June 23rd 2011

Arch Biopartners Scientists Awarded Funding to Further Develop Brain Tumour Targeting Technology

May 24th 2011

Arch Scientists to Present at ESF-LFUI Conference in Austria

May 10th 2011

Arch Scientists Create New Bio-Organic Metal That Is Harder, Resists Corrosion

April 11th 2011

Arch Cancer Therapeutics' Technology Update

Email News Subscriptions

Arch Biopartners send our press releases automatically via email. Check the boxes below to also receive updates on our science and investor news.
You'll receive an email confirming your subscription. Click the link in the email and you'll be set to go. You can unsubscribe at any time, and we will never share your email address.
Arch Biopartners
  • Home
  • About us
  • Our Science
    • Our Key Platforms
    • Our Publications
  • Our Team
    • Our Management
    • Our Principal Scientists
  • Investor Hub
    • Fundamentals
    • Reports and Filings
  • Contact Us
Contact us
+1 647 428 7031
info@archbiopartners.com
545 King Street West
Toronto, Ontario
M5V 1M1 Canada
Copyright Arch BioPartners 2015. All Rights Reserved. Legal notices.
PAGE TOP | TYPE SIZE | | RESET
Press Releases
  • Home
  • About us
  • Our Science
    • Our Key Platforms
      • AB569
      • MetaMx™
      • MetaBlok™
      • BORG
      • Treatments for Inflammation
    • Our Publications
      • AB569
      • Brain Tumor Stem Cell Targeting
      • BORG Peptide Solid Surface Interface
      • Treatments for Inflammation
  • Our Team
    • Our Management
    • Our Principal Scientists
      • Treatments for Inflammation
      • BORG Peptide
      • AB569 & Respiratory Pseudomonas
      • MetaBlok™ and MetaMx™
  • Investor Hub
    • Fundamentals
      • Press Releases
      • Investor Information
      • Stock Performance
    • Reports and Filings
      • Management Discussion and Analysis
      • Annual and Quarterly Reports
      • Proxies and Information Circulars
      • Material Change Documents
      • Other SEDAR Filings
  • Contact Us